Boosting Immune Function

Potent Mycoceuticals

This product contains a proprietary blend of the most potent and broad-based immune supporting mycoceuticals, i.e. mushroom varieties that have been used in many of the traditional Asian health supporting practices for thousands of years. They are grown by a proprietary process on organic brown rice culture, and harvested in the mycelial stage when their active constituents are at an even higher level than in the “fruiting body” or actual mushroom. The mycelial product is then dried at low temperature for stability. The culture conditions used for production of this unique mushroom blend prevent aluminum from entering the final product.

Since most species of mushroom actually concentrate aluminum from the environment, many commercially grown mushrooms contain high levels of this potentially harmful mineral.

There are several mushroom-derived products available which are processed extracts that are touted as potent “immune supporters”. Research has shown however, that what is gained in immune support potency is lost in function as an adaptogen, that is, the ability to regulate healthy function despite the types of challenges that may be present. To achieve the maximum benefit, an immune supporter requires adaptogenic qualities. For synergistic effects, yeast-derived beta-1, 3-glucan is also included to complement the many and varied mushroom derived beta-glucans, all of which have been shown to support high level healthy function of the immune cells of the body.

Flavonoids That Protect DNA

The second major category of ingredients in DNA-Immune is a broad spectrum of plant-derived flavonoids. These are chosen for their function, not only as potent antioxidants, but also for their ability to maintain healthy function of DNA in ways separate from their antioxidant activity. The recent amazing accomplishment of sequencing the human genome provides a window into secrets of life and health never before available.

Exposure to chemicals, harsh environmental factors and lower levels of protective phytonutrients in the diet and food supply, combine to create formidable challenges to maintaining and promoting the healthy function of DNA in our bodies. 

Multiple Flavonoid Compounds in DNA-Immune Include:

• Ellagic acid, a polyphenolic compound that exhibits activity helping to maintain healthy cells in a wide range of  tests, both  in-vitro (in laboratory) and in-vivo (in living systems). 

• Quercetin, a polyphenolic flavonol widely distributed in plants.

• Silymarin, a flavonoid found in Milk Thistle herb, showing potent antioxidant activity that supports healthy liver function.

• Epigallocatechin-3-gallate, derived from green tea.

• Japanese Knotweed, (Polygonium cuspidatum,) a plant long used in traditional Asian healing practices, is rich in a non-flavonoid polyphenol compound, also present in lower quantities in grape skins and grape leaves as well as a variety of berries and some nuts. These polyphenol compound (also classified as a phytoalexin) in grapes is thought to contribute (along with OPCs) to the higher level of cardiovascular health seen in French wine drinkers who consume a high fat diet, (the so-called French Paradox). The polyphenolics in Japanese Knotweed act as potent antioxidants, and induce important enzymes in the liver that contribute to healthy cleansing processes of the body.

• Curcumin, a potent antioxidant produced from the spice turmeric.

All of these compounds share a common chemical structure, termed phenolic (though the latter two compounds are not technically flavonoids because they don’t contain the flavone ring, they are all closely related phenols).

Although they have complicated chemical sounding names, they are widely distributed in edible plants. They are found in particularly high concentrations in nuts, berries, spices, herbs, seeds, and teas.

The enzyme bromelain (purified from pineapples) is included in the DNA-Immune formula to increase the bioavailability of these flavonoids and for its ability to maintain and promote the healthy function of immune cells known as macrophages.

Immune Boosting Botanicals

The third major category of components in DNA-Immune are botanicals (plant extracts). These are chosen for their high flavonoid content, their antioxidant activity (as measured in the scientific laboratory) their traditional use in maintaining and supporting healthy immune function, and their ability to promote and maintain healthy DNA. Included in this category are:

• Echinacea root and whole plant extracts that contain alkylamides, polyacetylenes, caffeic acid derivative and polysaccharides, all with immune-enhancing properties.

• Astragalus root extract, classified as a “superior herb” in the classical ancient Chinese treatise Shen Nung Pen Tsao Ching.  Astragalus root extract contains flavonoids, polysaccharides, and triterpene glycosides.

• Ashwagandha root, containing glycowithanolides, which are potent antioxidants. Experimental and clinical research has suggested that they have anti-aging, anti-stress, and immune promoting qualities and also enhance mental clarity.

• Ligustrum lucidum (Privet berry extract).

• Green tea (leaf extract).

• Siberian ginseng root extract, used traditionally for thousands of years as a tonic for energy and vitality and used in traditional Chinese health practices, particularly to promote respiratory tract health.

• American ginseng (panax quinquefolius) contains ginsenosides, which support the immune system and fight fatigue and stress by supporting the adrenal glands and the use of oxygen by exercising muscles.

• Turmeric root (95% circumin extract).

• Noni (freeze dried powder of juiced fruit).

• Schizandra chinensis (fruit extract).

• Milk Thistle seed (80% Silymarin extract).

• Gotu kola leaf extract, a popular herb in the Ayurvedic tradition, used to help maintain and promote healthy skin and to enhance mental clarity and vitality.

• Olive (leaf extract).

• Aloe vera (freeze dried whole leaf gel).

Co-Q-10 and L-Carnitine For Essential Energy Production

The fourth category making up DNA- Immune are nutrients that play a key role in cellular energy production, since high level immune function requires large amounts of cellular energy. L-carnitine is an amino acid derived compound necessary for transport of fatty acids as fuel into mitochondria, the “furnaces” of the cell.  Co-Q-10, likewise, plays a key role in the ability of the mitochondria to produce cellular energy, while protecting mitochondrial membranes from free radical attack. Finally, folic acid, vitamin B-12, and betaine are included, for their role in methylation reactions, which are essential to maintaining healthy DNA, and for the role folic acid plays in maintaining and strengthening healthy chromosomes.

The fifth and final component of DNA-Immune is inositol hexaphosphate (IP-6), otherwise known as phytic acid, a major component of plant fiber. Animal studies have shown a wide variety of beneficial effects of this compound including promoting and maintaining high level healthy immune function, healthy blood sugar metabolism, and antioxidant activity.

These five categories of components:  mycoceuticals, flavonoids, botanical extracts, methylation and energy specific nutrients, and inositol hexaphosphate, combine to make a truly unique nutraceutical product designed to help you maintain overall good health at its highest level by protecting your cellular DNA and supporting healthy immune system function. Making it a regular part of your daily diet, and using larger amounts during periods of stress and/or immune challenges, can enhance your level of wellness considerably. Try it for a few months and see for yourself.  Keep in mind—you never know what you’re preventing!

References:
1. Yang CS, Landau JM, Huang MT, Newmark HL Inhibition of carcinogenesis by dietary polyphenolic compounds Annu Rev Nutr 2001;21:381-406
2. Hertog, Feskens, Hollman et al. Dietary antioxidant flavonoid and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 1993 Oct 23; 342(8878)
3. Thulstrup PW;Thormann T; et. al. Interaction between ellagic acid and calf thymus DNA studied with flow linear dichroism UV-VIS spectroscopy. Biochem Biophys Res Commun 1999 Nov19;254(2):416-21.
4. Thresiamma KC, George J, Kuttan R. Protective effect of curcumin, ellagic acid, and bixin on radiation induced genotoxicity. J Exp Clin Cancer Res 1998 Dec;17(4):431-4.
5. Satoskar RR, Shah SJ, Shenoy SG. Evaluation of anti-inflammatory property of curcumin in patients with postoperative inflammation.  Int J Clin Pharmacol Therapy Toxicol 1986;24(12):651-654.
6. Shoskes DA, Zeitlin SI, Shahed A, Rajfer J.  Quercetin in men with category III chronic prostatitis:  A preliminary prospective, double-blind, placebo-controlled trial.  Urology 1999 Dec;54(6):960-3.
7. See DM; Broumand N; Sahl L; Tilles JG.  In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacol 1997;35:229-35.
8. Eckert K; Grabowska E, et al. Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients. Oncol Rep 1999 Nov-Dec; 6(6)
9 Ziauddin M;Phansalkar N; Patki P; et. al. Studies on the immunomodultory effects of Ashwagandha.  J. Ethnopharamacol 1996 Feb;50(2):69-76.
10. Fleming HP, Walter WM, Etchells JL. Antimicrobial properties of oleuropein and products of its hydrolosis from green olives.  Applied Microbiol 1973;26:777-82.
11. Shamsuddin AM. Metabolism and cellular functions of IP-6: a review. Anticancer Res 1999 Sept-Oct; 19(5A)
12. Bohn B; Nebe CT; Birr C. Flow cytometric studies with eleutherococcus senticosus extract as an immunomodulatory agent.  Arzneimittelforschung 1987 Oct;37(10):1193-6.
13. Kim, KC; Kim IG. Ganoderma lucidum extract protects DNA from strand breakage caused by hydroxyl radical and UV irradiation.  Int J Mol Med 1999 Sep;4(3):273-7
14. De Simone C, Ferrari M, Lozzi A, et al. Vitamins and immunity II:  Influence of L-carnitine on the immune system. Acta Vitaminol Enzymol 1982;4(1-2):135-40.

DIRECTIONS:  Two tablets two times a day.

Contains no artificial preservatives, sugar, starch, caffeine, salt, wheat, gluten, corn, milk, egg, shellfish, soya derivatives, artificial sweetening, flavoring or coloring agents.

This product is not tested on animals. Contains no ingredients from animal sources. 

Supplement Facts
Serving Size	2	Tablets
Servings Per Container	60
Amount Per Serving		% Daily Value
Calories	5
Total Carbohydrate	1	g	0%*
Folic Acid	40	mcg	10%
Vitamin B-12 (Cyanocobalamin)	50	mcg	833%
Mycoceutical Mix	250	mg	**
Beta 1,3 Glucans (from Beta
Glucan Complex)	40	mg	**
Betaine HCI	100	mg	**
Bromelain	33	mg	**
Coenzyme Q-10	4	mg	**
Inositol	90	mg	**
Inositol Hexaphosphate	70	mg	**
L-Carnitine	20	mg	**
Quercetin	40	mg	**
Japanese Knotweed Extract	20	mg	**
Aloe Vera Leaf Gel	10	mg	**
American Ginseng (Panax
quinquefolius L.) Root Extract	20	mg	**
Ginsenosides	1	mg	**
Ashwagandha Rhizome Extract	70	mg	**
Astragalus Rhizome Extract	70	mg	**
Chinese (Baikal) Skullcap
Aerial Parts Extract	40	mg	**
Echinacea Blend	100	mg	**
Gotu Kola Aerial Parts Extract	40	mg	**
Asiaticosides	4	mg	**
Total Triterpenes	12	mg	**
Green Tea Leaf Extract	80	mg	**
Green Tea Polyphenols	32	mg	**
Milk Thistle Seed Extract	30	mg	**
Silymarin	24	mg	**
Noni (Morinda citrifolia L.) Fruit	15	mg	**
Olive (Olea europaea L.) Leaf Extract	20	mg	**
Oleuropein	1	mg	**
Pomegranate (Punica granatum
L.) Whole Fruit Extract	18	mg	**
Ellagic Acid	7	mg	**
Privet Fruit (Berry)	70	mg	**
Schisandra Chinensis
Fruit Extract	40	mg	**
Siberian Ginseng
(Eleutherococcus senticosus
(Rupr. et Maxim.) Maxim.)
Root Extract	30	mg	**
Eleutherosides	0.2	mg	**
Turmeric Root Extract	40	mg	**
Curcuminoids	38	mg	**
*Percent Daily Values are based on 2,000 calorie diet.
**Daily Value not established.

OTHER INGREDIENTS:  Mycoceutical (Mushroom) Mixture (A proprietary blend of mushroom powders: Aerial Parts of Reishi, Maitake (Grifola frondosa (Dicks) S.F. Gray), Shiitake, Turkey Tail (Coriolus versicolor (Fr.) Quel.), Caterpillar (Cordyceps), Monkey Head (Hericium erinaceus Persoon), Split Gill (Schizophyllum commune Fries), Fu Ling, White Woodear (Tremella fuciformis Berk.)), Dicalcium Phosphate, Betaine HCl, Echinacea Mixture (Echinacea Purpurea Root Extract, Echinacea Angustifolia Whole Herb Extract, Echinacea Purpurea Whole Herb Extract, Echinacea Angustifolia Root Extract), Stearic Acid, Polyvinylpyrrolidone, Silica, Microcrystalline Cellulose, Magnesium Stearate, Natural Caramel and Vanilla Flavor, and PhytoZyme™ proprietary blend (Bromelain, Papain, Aloe Vera, Alfalfa, Parsley, and vegetable and fruit concentrates from Carrots, Broccoli, Spinach, Cauliflower, Asparagus, Celery, Beet, Chili Pepper, Green Bean, Pea, Sweet Potato, Cucumber, Pumpkin, Snow Pea, Tomato, Zucchini, Lima Beans, Mushroom, Banana, Cantaloupe, Cranberry, Guava, Lemon, Mango, Orange, Papaya, Peach, Pineapple and Grapefruit).

Product No:   6110 

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DNA Immune